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2023

Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome.

Risal S*, Li C*, Luo Q*, Fornes R, Lu H, Eriksson G, Manti M, Ohlsson C, Lindgren E, Crisosto N, Maliqueo M, Echiburú B, Recabarren S, Petermann TS, Benrick A, Brusselaers N, Qiao J, Deng Q#, Stener-Victorin E#. (# shared corresponding author)

Cell Rep Med. 2023 May 16;4(5):101035. doi: 10.1016/j.xcrm.2023.101035. Epub 2023 May 5.

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Transcriptomic survey of key reproductive and metabolic tissues in mouse models of polycystic ovary syndrome

Pei Y*, Risal S*, Jiang H, Lu HJ, Lindgren E, Stener-Victorin E#, Deng Q#

Commun Biol 6, 69 (2023). doi: 10.1038/s42003-022-04362-0

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Epiblast-like stem cells established by Wnt/b-catenin signaling manifest distinct features of formative pluripotency and germline competence

Luo Q, Pui HP, Chen J, Yu L, Jannig PJ, Pei Y, Zhao LX, Chen X, Petropoulos S, Ruas JL, Wu J, Deng Q

Cell Reports 42, 112021, January 31, 2023. doi: 10.1016/j.celrep.2023.112021

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Resetting histone modifications during human prenatal germline development

Gao R, Zeng S, Yang D, Li X, Liu W, Gao Y, Bai D, Zhang L, Chen C, Kang Y, Wang B, Hong W, Wang M, Yin J, Wang H, Deng Q, Gao S, Zhang Y, Chen J.

Cell Discov . 2023 Feb 3;9(1):14. doi: 10.1038/s41421-023-00519-1.

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2022

In Vitro Differentiation of Murine Embryonic Stem Cells (ESCs) into Primordial Germ Cell-like Cells (PGCLCs)

Pui HP, Deng Q

Methods Mol Biol. 2022; 2490:213-233. doi: 10.1007/978-1-0716-2281-0_16.

 

Differentiation of Human-Induced Pluripotent Stem Cells (hiPSCs) into Human Primordial Germ Cell-like Cells (hPGCLCs) In Vitro

Reda A, Stukenborg JB, Deng Q

Methods Mol Biol. 2022; 2490:235-249. doi: 10.1007/978-1-0716-2281-0_17.

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A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome

Liu Q, Tang B, Zhu Z, Kraft P, Deng Q, Stener-Victorin E, Jiang X

Diabetologia. 2022 Sep;65(9):1483-1494. doi: 10.1007/s00125-022-05746-x.

 

ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes

Ma Q, Xiao Y, Xu W, Wang M, Li S, Yang Z, Xu M, Zhang T, Zhang ZN, Hu R, Su Q, Yuan F, Xiao T, Wang X, He Q, Zhao J, Chen ZJ, Sheng Z, Chai M, Wang H, Shi W, Deng Q#, Cheng X#, Li W# (# shared corresponding author)

Nat Commun. 2022 Jul 16;13(1):4142. doi: 10.1038/s41467-022-31829-9.

Our work is highlighted in Nature reviews endocrinology and Science Signaling

 

Elastic dosage compensation by X-chromosome upregulation

Lentini A, Cheng H, Noble JC, Papanicolaou N, Coucoravas C, Andrews N, Deng Q, Enge M, Reinius B

Nat Commun, 2022 Apr 6;13(1):1854. doi: 10.1038/s41467-022-29414-1.

 

Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis

Liu Q, Zhu Z, Kraft P, Deng Q, Stener-Victorin E, Jiang X

BMC Med. 2022 Feb 11;20(1):66. doi: 10.1186/s12916-022-02238-y.

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2021

Single-cell analysis reveals MHCII expressing keratinocytes in pressure ulcers with worse healing outcomes

Dongqing Li, Shangli Cheng, Yu Pei, Pehr Sommar, Jaanika Kärner, Eva K Herter, Maria A Toma, Letian Zhang, Kim Pham, Yuen Ting Cheung, Zhuang Liu, Xingqi Chen, Liv Eidsmo, Qiaolin Deng#, Ning Xu Landén# (# shared corresponding author)

J Invest Dermatol . 2021 Sep 15;S0022-202X(21)02167-9. doi: 10.1016/j.jid.2021.07.176.

 

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

O. C. Bedoya-Reina, W. Li, M. Arceo, M. Plescher, P. Bullova, H. Pui, M. Kaucka, P. Kharchenko, T. Martinsson, J. Holmberg, I. Adameyko, Q. Deng, C. Larsson, C. C. Juhlin, P. Kogner & S. Schlisio

Nat Commun. 2021 Sep 7;12: 5309. https://doi.org/10.1038/s41467-021-24870-7.

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Spatial RNA Sequencing Identifies Robust Markers of Vulnerable and Resistant Human Midbrain Dopamine Neurons and Their Expression in Parkinson's Disease

Julio Aguila, Shangli Cheng, Nigel Kee, Ming Cao, Menghan Wang, Qiaolin Deng#, Eva Hedlund# (# shared corresponding author)

Front Mol Neurosci. 2021 Jul 8;14:699562. doi: 10.3389/fnmol.2021.699562.

 

Epigenetic inheritance of polycystic ovary syndrome - challenges and opportunities for treatment

Elisabet Stener-Victorin, Qiaolin Deng

Nat Rev Endocrinol. 2021 Jul 7. doi: 10.1038/s41574-021-00517-x.

Featured in the cover

 

Transmission of polycystic ovary syndrome via epigenetic inheritance

Elisabet Stener-Victorin, Qiaolin Deng

Trends Mol Med. 2021 Jun 11;S1471-4914(21)00129-5. doi: 10.1016/j.molmed.2021.05.005.

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Is there a shared genetic basis and causal relationship between polycystic ovary syndrome and psychiatric disorders: evidence from a comprehensive genetic analysis

Xia Jiang, Qiaolin Deng, Elisabet Stener-Victorin

Hum Reprod. 2021 May 29;deab119. doi: 10.1093/humrep/deab119.

 

Prenatal androgen exposure causes a sexually dimorphic transgenerational increase in offspring susceptibility to anxiety disorders

Sanjiv Risal, Maria Manti, Haojiang Lu, Romina Fornes, Henrik Larsson, Anna Benrick, Qiaolin Deng, Carolyn E. Cesta, Mina A. Rosenqvist & Elisabet Stener-Victorin

Transl Psychiatry. 2021 Jan 13;11(1):45. doi: 10.1038/s41398-020-01183-9.

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2020

Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice

Maria Manti, Han-Pin Pui, Sonja Edström, Sanjiv Risal, Haojiang Lu, Eva Lindgren, Claes Ohlsson, Elisabet Jerlhag, Anna Benrick, Qiaolin Deng, Elisabet Stener-Victorin

FASEB J. 2020 Nov;34(11):14440-14457. doi: 10.1096/fj.202001060R.

 

LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy

Susanne Nichterwitz, Jik Nijssen, Helena Storvall, Christoph Schweingruber, Laura Helen Comley, Ilary Allodi, Mirjam van der Lee, Qiaolin Deng, Rickard Sandberg, Eva Hedlund

Genome Res. 2020 Aug;30(8):1083-1096. doi: 10.1101/gr.265017.120.

 

2019

Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome. [GSE133100]

Sanjiv Risal, Yu Pei, Haojiang Lu, Maria Manti, Romina Fornes, Han-Pin Pui, Zhiyi Zhao, Julie Massart, Claes Ohlsson, Eva Lindgren, Nicolas Crisosto, Manuel Maliqueo, Barbara Echiburú, Amanda Ladrón de Guevara, Teresa Sir-Petermann, Henrik Larsson, Mina A Rosenqvist, Carolyn E Cesta, Anna Benrick, Qiaolin Deng, Elisabet Stener-Victorin

Nat Med. 2019 Dec;25(12):1894-1904. doi: 10.1038/s41591-019-0666-1.

 

Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization.

Ali Z, Mukwaya A, Biesemeier A, Ntzouni M, Ramsköld D, Giatrellis S, Mammadzada P, Cao R, Lennikov A, Marass M, Gerri C, Hildesjö C, Taylor M, Deng Q, Peebo B, Del Peso L, Kvanta A, Sandberg R, Schraermeyer U, Andre H, Steffensen JF, Lagali N, Cao Y, Kele J, Jensen LD

Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1402-1418. doi: 10.1161/ATVBAHA.118.312190.

 

Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development.

Shangli Cheng, Yu Pei, Liqun He, Guangdun Peng, Björn Reinius, Patrick P L Tam, Naihe Jing, Qiaolin Deng

Cell Rep. 2019 Mar 5;26(10):2593-2607.e3. doi: 10.1016/j.celrep.2019.02.031.

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2018

GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes.

Amol K Bhandage, Zhe Jin, Sergiy V Korol, Qiujin Shen, Yu Pei, Qiaolin Deng, Daniel Espes, Per-Ola Carlsson, Masood Kamali-Moghaddam, Bryndis Birnir

EBioMedicine. 2018 Apr;30:283-294. doi: 10.1016/j.ebiom.2018.03.019.

 

LCM-Seq: A Method for Spatial Transcriptomic Profiling Using Laser Capture Microdissection Coupled with PolyA-Based RNA Sequencing.

Susanne Nichterwitz, Julio Aguila Benitez, Rein Hoogstraaten, Qiaolin Deng, Eva Hedlund

Methods Mol Biol. 2018;1649:95-110. doi: 10.1007/978-1-4939-7213-5_6.

 

Single-cell RNA sequencing: Technical advancements and biological applications

Eva Hedlund, Qiaolin Deng

Mol Aspects Med. 2018 Feb;59:36-46. doi: 10.1016/j.mam.2017.07.003.

2017

Revealing allele-specific gene expression by single-cell transcriptomics.

Julio Aguila Benitez, Shangli Cheng, Qiaolin Deng

Int J Biochem Cell Biol. 2017 Sep;90:155-160. doi: 10.1016/j.biocel.2017.05.029.

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2016

Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization.

Björn Reinius, Jeff E Mold, Daniel Ramsköld, Qiaolin Deng, Per Johnsson, Jakob Michaëlsson, Jonas Frisén, Rickard Sandberg

Nat Genet. 2016 Nov;48(11):1430-1435. doi: 10.1038/ng.3678.

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Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation. [GSE74155]

Geng Chen, John Paul Schell, Julio Aguila Benitez, Sophie Petropoulos, Marlene Yilmaz, Björn Reinius, Zhanna Alekseenko, Leming Shi, Eva Hedlund, Fredrik Lanner, Rickard Sandberg, Qiaolin Deng

Genome Res. 2016 Oct;26(10):1342-1354. doi: 10.1101/gr.201954.115.

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Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons.

Hélène Doucet-Beaupré, Catherine Gilbert, Marcos Schaan Profes, Audrey Chabrat, Consiglia Pacelli, Nicolas Giguère, Véronique Rioux, Julien Charest, Qiaolin Deng, Ariadna Laguna, Johan Ericson, Thomas Perlmann, Siew-Lan Ang, Francesca Cicchetti, Martin Parent, Louis-Eric Trudeau, Martin Lévesque

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4387-96. doi: 10.1073/pnas.1520387113.

 

Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling. [GSE76514]

Susanne Nichterwitz, Geng Chen, Julio Aguila Benitez, Marlene Yilmaz, Helena Storvall, Ming Cao, Rickard Sandberg, Qiaolin Deng, Eva Hedlund

Nat Commun. 2016 Jul 8;7:12139. doi: 10.1038/ncomms12139.

 

Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors.

Eva Hedlund, Laure Belnoue, Spyridon Theofilopoulos, Carmen Salto, Chris Bye, Clare Parish, Qiaolin Deng, Banafsheh Kadkhodaei, Johan Ericson, Ernest Arenas, Thomas Perlmann, András Simon

Sci Rep. 2016 Jun 1;6:26448. doi: 10.1038/srep26448.

 

Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells.

Eike-Benjamin Braune, Yat Long Tsoi, Yee Peng Phoon, Sebastian Landor, Helena Silva Cascales, Daniel Ramsköld, Qiaolin Deng, Arne Lindqvist, Xiaojun Lian, Cecilia Sahlgren, Shao-Bo Jin, Urban Lendahl

Stem Cell Reports. 2016 May 10;6(5):643-651. doi: 10.1016/j.stemcr.2016.03.004.

 

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos.

Sophie Petropoulos, Daniel Edsgärd, Björn Reinius, Qiaolin Deng, Sarita Pauliina Panula, Simone Codeluppi, Alvaro Plaza Reyes, Sten Linnarsson, Rickard Sandberg, Fredrik Lanner

Cell. 2016 May 5;165(4):1012-26. doi: 10.1016/j.cell.2016.03.023. Epub 2016 Apr 7.

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Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq

Cathryn R Cadwell, Athanasia Palasantza, Xiaolong Jiang, Philipp Berens, Qiaolin Deng, Marlene Yilmaz, Jacob Reimer, Shan Shen, Matthias Bethge, Kimberley F Tolias, Rickard Sandberg, Andreas S Tolias

Nat Biotechnol. 2016 Feb;34(2):199-203. doi: 10.1038/nbt.3445.

 

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